Preliminary Study on Antimalarial Agent From Indonesian Swietenia Mahagoni and Kibatalia Arborea

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Bawon Triatmoko Dwi Koko Pratoko Antonius Nugraha Widhi Pratama Yoshinta Debi Purnomo Tinton Agung Laksono Ari Satia Nugraha

Abstract

Malaria is a global public health concern due to the increase of resistance to antimalarials, therefore the search for new antimalarials is of importance. This study was conducted to
explore the antimalarial activity of Swietenia mahagoni and
Kibatalia arborea in the form of crude methanolic extract. The
plants were collected from Klaten-Central Java, and Batu-East
Java, Indonesia. In vitro antimalarial assay was done against
Plasmodium falciparum. Phytochemical studies were done
chemically using Dragendorff’s reagent and spectroscopically
using the 1H-NMR technique. Results show that the extract
indicated positive antimalarial activity. Preliminary chemotype studies revealed the extract constitutes alkaloid compounds in which proton NMR indicated a typical aromatic alkaloid molecular structure. In conclusion, S. mahagoni K. arborea are potential for an antimalarial agent and further studies are necessary to obtain the bioactive compounds responsible for the claimed activity.

Article Details

How to Cite
TRIATMOKO, Bawon et al. Preliminary Study on Antimalarial Agent From Indonesian Swietenia Mahagoni and Kibatalia Arborea. Proceedings of the International Conference on Green Technology, [S.l.], v. 10, p. 13-16, dec. 2019. ISSN 2580-7099. Available at: <http://conferences.uin-malang.ac.id/index.php/ICGT/article/view/1113>. Date accessed: 07 apr. 2020.
Section
Pharmacy

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