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Malaria is a global public health concern due to the increase of resistance to antimalarials, therefore the search for new antimalarials is of importance. This study was conducted to
explore the antimalarial activity of Swietenia mahagoni and
Kibatalia arborea in the form of crude methanolic extract. The
plants were collected from Klaten-Central Java, and Batu-East
Java, Indonesia. In vitro antimalarial assay was done against
Plasmodium falciparum. Phytochemical studies were done
chemically using Dragendorff’s reagent and spectroscopically
using the 1H-NMR technique. Results show that the extract
indicated positive antimalarial activity. Preliminary chemotype studies revealed the extract constitutes alkaloid compounds in which proton NMR indicated a typical aromatic alkaloid molecular structure. In conclusion, S. mahagoni K. arborea are potential for an antimalarial agent and further studies are necessary to obtain the bioactive compounds responsible for the claimed activity.
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