Systematic Literature Review Potential of Sappan Wood Plants (Caesalpinia sappan L.) As Anticancer
Abstract
Sappan wood (Caesalpinia sappan L.) is a plant known to have an effect as an anticancer. The use of sappan wood as an anticancer scientifically has done much research, but it has not been delivered holistically. Furthermore, a systematic literature review is needed to get a wider understanding and the data that is more accurate so that it can be a reference for the researcher in developing a new medicine for anticancer. This literature research has the purpose of determining the sappan wood‟s compound that has acted as an anticancer, determining the prediction of anticancer activity on sappan wood in silico method, and the activities of anticancer in vitro and in vivo studies, and also determining how the mechanism is to develop the compounds as an anticancer. This research uses a systematic literature review, and the data are obtained by the PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-analyses). The article searching method uses a database in Google Scholar, ScienceDirect, SpringerLink, and PubMed, which is then analyzed so that the researcher obtains 27 suitable articles. The analysis result exhibits that the compound inside sappan wood that activity as an anticancer are brazilin, brazilein, sappanchalcone, 3-deoxysappanchalcone, caesalpiniaphenol G, dan caesalpiniaphenol H. Sappan wood is proven to have a prediction concerning anticancer activities in silico, and the anticancer activities in vitro and in vivo through several mechanisms. They are apoptosis induction, cell cycle inhibition, antimetastasis, antiproliferative, inhibition of HO-1 expression, and inhibition of BAF.
References
Agustin, T. (2021) „Efektivitas Nutrasetikal Sebagai Penghambat Kanker Terhadap Progresivitas Kanker Payudara‟, Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan, 7(1), p. 11. doi: 10.33772/pharmauho.v7i1.13524.
Azeez, J. M. et al. (2015) „Progesterone regulates the proliferation of breast cancer cells – In vitro evidence‟, Drug Design, Development and Therapy, 9, pp. 5987–5999. doi: 10.2147/DDDT.S89390.
Bailly, C. and Vergoten, G. (2021) „Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study‟, Current Research in Pharmacology and Drug Discovery, 2(August), pp. 1–8. doi: 10.1016/j.crphar.2021.100059.
Chau, L. Y. (2015) „Heme oxygenase-1: Emerging target of cancer therapy‟, Journal of Biomedical Science, 22(1), pp. 1–7. doi: 10.1186/s12929-015-0128-0.
Dewi Harnis, A. P. et al. (2020) „Virtual Inhibition Analysis of Bioactive Compound Brazilin (Caesalpinia sappan L.) Toward Progesterone Receptor or Lonaprisan in Breast Cancer Proliferation‟, Biotropika: Journal of Tropical Biology, 8(2), pp. 62–70. doi: 10.21776/ub.biotropika.2020.008.02.01.
Global Cancer Observatory (2020) „Cancer Incident in Indonesia‟, International Agency for Research on Cancer, 858, pp. 1–2.
Gorjánácz, M. (2014) „Nuclear assembly as a target for anti-cancer therapies‟, Nucleus (United States). doi: 10.4161/nucl.27928.
Handayani, S. et al. (2016) „Brazilein in combination with cisplatin inhibit proliferation and migration on highly metastatic cancer cells, 4T1‟, core.ac.uk, 21(1), pp. 38–47. Available at: https://core.ac.uk/download/pdf/298144682.pdf (Accessed: 9 December 2021).
Hanif, N., Hermawan, A. and Meiyanto, E. (2019) „Caesalpinia sappan L. Ethanolic Extract Decrease Intracellular ROS Level and Senescence of 4T1 Breast Cancer Cells‟, Indonesian Journal of Cancer Chemoprevention, 10(1), p. 16. doi: 10.14499/indonesianjcanchemoprev10iss1pp16-23.
Haryanti, S., Pramono, S., Murwanti, R., Meiyanto, E., Large Research and Development of Medicinal Plants and Traditional Medicine, B., & Health of the Republic of Indonesia, K. (2016). The synergistic effect of doxorubicin and ethanolic extracts of Caesalpinia sappan L. wood and Ficus septica Burm. f. leaves on viability, cell cycle progression.Indonesian Journal of Biotechnology, 21(1), 29–37. doi: 10.22435/hsji.v9i1.486.
Haryanti, S., Widiyastuti, Y. and Rahmawati, N. (2018) „Cytotoxic and MMPs inhibitory activities of Sappan Wood (Caesalpiniasappan L.): various extracts on 4T1 breast cancer cell line‟, Health Science Journal of Indonesia, 9(1), pp. 51–56. doi: 10.22435/hsji.v9i1.483.
Horneber, M. et al. (2012) „How many cancer patients use complementary and alternative medicine: A systematic review and metaanalysis‟, Integrative Cancer Therapies, 11(3), pp. 187–203. doi: 10.1177/1534735411423920.
Hung, T. M. et al. (2013) „Cytotoxic activity of new phenolic compounds from vietnamese caesalpinia sappan‟, Bioscience, Biotechnology and Biochemistry, 77(12), pp. 2378–2382. doi: 10.1271/BBB.130493.
Hung, T. M., Dang, N. H. and Dat, N. T. (2014) „Methanol extract from Vietnamese Caesalpinia sappan induces apoptosis in HeLa cells‟, Biological Research, 47(1). doi: 10.1186/0717-6287-47-20/fulltext.html.
Husna , U. , Putu , N. , Laksmiani , L. , Susidarti , R. A. , & Meiyanto , E. (2017). Ethyl acetate fraction of Caesalpinia sappan L. enhances cisplatin‟s cytotoxicity on HeLa cells via G1 and S arrest through p53 expression.Indonesian Journal of Cancer Chemoprevention (IJCC), 8(2), 51–60.
Jang, H. Y., Hong, O. Y., Chung, E. Y., Park, K. H., & Kim, J. S. (2020). Roles of JNK / Nrf2 Pathway on Hemin-Induced Heme Activation, Oxygenase- Breast, Mcf- Human Cells. Medicine, 56(268), 1–11. Available at: https://www.mdpi.com/1648-9144/56/6/268 (Accessed: 9 December 2021).
Jenie, R. I. et al. (2017) „Cytotoxic and Antimetastasis Effect of Ethyl Acetate Fraction from Caesalpinia sappan L. on MCF-7/HER2 Cells‟, Indonesian Journal of Cancer Chemoprevention, 8(1), p. 42. doi: 10.14499/indonesianjcanchemoprev8iss1pp42-50.
Jenie, R. I. et al. (2018) „The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubicin on MCF-7/HER2 Cells.‟, Advanced pharmaceutical bulletin, 8(3), pp. 507–516. doi: 10.15171/apb.2018.059.
Khamsita, R. et al. (2012) „Ethanolic extract of Secang (Caesalpinia sappan L.) wood performs as chemosensitizing agent through apoptotic induction on breast cancer MCF-7 Cells‟, ijcc.chemoprev.org. Available at: http://ijcc.chemoprev.org/index.php/ijcc/article/view/69 (Accessed: 8 December 2021).
Kim, B. et al. (2012) „Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells.‟, Journal of agricultural and food chemistry, 60(39), pp. 9882–9889. doi: 10.1021/jf302527p.
Kim, S.-H. et al. (2016) „Brazilin isolated from Caesalpinia. sappan suppresses nuclear envelope reassembly by inhibiting BAF phosphorylation‟, Citeseer, 352, pp. 175–184. doi: 10.1124/jpet.114.218792.
Kim, S. H. et al. (2012) „Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells‟, Journal of Agricultural and Food Chemistry, 60(39), pp. 9882–9889. doi: 10.1021/JF302527P.
Kwak, A.-W. et al. (2021) „The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells‟, Phytomedicine, 86, p. 153564. doi: https://doi.org/10.1016/j.phymed.2021.153564.
Lee, D. et al. (2013) „Brazilin inhibits growth and induces apoptosis in human glioblastoma cells‟, mdpi.com. Available at: https://www.mdpi.com/47386 (Accessed: 9 December 2021).
Lee, Y. et al. (2011) „Mechanism of sappanchalcone-induced growth inhibition and apoptosis in human oral cancer cells‟, Elsevier. Available at: https://www.sciencedirect.com/science/article/pii/S0887233311002517 (Accessed: 14 March 2022).
Ngernnak, C., Panyajai, P. and Anuchapreeda, S. (2018) „Phytochemical and cytotoxic investigations of the heartwood of Caesalpinia sappan linn‟. Available at: http://cmuir.cmu.ac.th/handle/6653943832/58994 (Accessed: 8 December 2021).
Nurzijah, I. et al. (2012) „Secang (Caesalpinia sappan L.) Heartwood Ethanolic Extract Shows Activity as Doxorubicin Co-chemotherapeutic Agent by Apoptotis Induction on T47D Breast‟, ijcc.chemoprev.org. Available at: https://www.ijcc.chemoprev.org/index.php/ijcc/article/view/59 (Accessed: 8 December 2021).
Pratiwi, S. R., Widianti, E. and Solehati, T. (2017) „Gambaran Faktor-Faktor yang Berhubungan dengan Kecemasan Pasien Kanker Payudara dalam Menjalani Kemoterapi‟, Jurnal Pendidikan Keperawatan Indonesia, 3(2), p. 167. doi: 10.17509/jpki.v3i2.9422.
Purwaningsih, E. (2014) „Pemendekan Telomer Dan Apoptosis Telomere Shorthening And Apoptosis‟, Jurnal Kedokteran Yarsi, 22(2), pp. 132–141.
Rachmady, Rahmawaty et al. (2017) „Antiproliferative effect of secang heartwood ethanolic extract (Caesalpinia sappan L.) on HER2-positive breast cancer cells‟, Indonesian Journal of Cancer Chemoprevention (IJCC), 7(1). Available at: http://ijcc.chemoprev.org/index.php/ijcc/article/view/95 (Accessed: 8 December 2021).
Ratnasari, A. A. et al. (2016) „Hubungan Ekspresi NFκB dengan Respons Radiasi Kanker Serviks Stadium Lokal Lanjut‟, eJournal Kedokteran Indonesia, 4(1). doi: 10.23886/ejki.4.5906.31-6.
Riris Istighfari Jenie, Sri Handayani, Ratna Asmah Susidarti, Linar Zalinar Udin, E. M. (2018). The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubici.pdf.Advanced Pharmaceutical Bulletin, 8(3), 507–516.
Rivanti, E., Shabrina, B., Nurzijah, I., … C. A.-… J. of C., & 2016, U. (2017). Heartwood of Sappan (Caesalpinia sappan L.) ethanolic extract show selective cytotoxic activities on T47D and Widr cells but not on Hela Cells. Indonesian Journal of Cancer Chemoprevention (IJCC), 7(2), 60–67.
Robinson, T. (1995). Organic Content of High Plants Ed.6. In Kosasih Padmawinata (Ed.),ITB-press (Edition 6).
Sarmoko, L. and (2012) Regulasi Siklus Sel, Cancer Chemoprevention Research Center Universitas Gadjah Mada. Available at: https://ccrc.farmasi.ugm.ac.id/?p=2584.
Tao, L., Li, J. and And, J. Z. (2011) „Brazilein overcame ABCB1-mediated multidrug resistance in human leukaemia K562/AO2 cells‟, African Journal of Pharmacy and Pharmacology, 5(16). doi: 10.5897/AJPP11.099.
Tao, L., Li, J. and Zhang, J. (2013) „Brazilein, a compound isolated from Caesalpinia sappan Linn., induced growth inhibition in breast cancer cells via involvement of GSK-3β/β-Catenin/cyclin D1 pathway.‟, Chemico-biological interactions, 206(1), pp. 1–5. doi: 10.1016/j.cbi.2013.07.015.
Tirtanirmala, P. et al. (2015) „Cytotoxic and apoptotic-inducing effect of fraction containing Brazilein from Caesalpinia sappan L. and cisplatin on T47D cell lines‟, Indonesian Journal of Cancer Chemoprevention (IJCC), 6(3), pp. 89–96. Available at: https://iscc-indonesia.org/chemoprev.org/ijcc/index.php/ijcc/article/view/91 (Accessed: 8 December 2021).
Utami, D. T. et al. (2020) „Co-treatment of Brazilein Enhances Cytotoxicity of Doxorubicin on WiDr Colorectal Cancer Cells Through Cell Cycle Arrest‟, Indonesian Biomedical Journal, 12(4), pp. 376–382. doi: 10.18585/INABJ.V12I4.1293.
Utomo, R. Y. et al. (2018) „Enhancement of cytotoxicity and apoptosis induction of Doxorubicin by Brazilein containing fraction of secang (Caesalpinia sappan L.) on T47D Cells‟, Indonesian Journal of Cancer Chemoprevention (IJCC), 9(1), 32–40. Available at: https://iscc-indonesia.org/chemoprev.org/ijcc/index.php/ijcc/article/view/208 (Accessed: 9 December 2021
Azeez, J. M. et al. (2015) „Progesterone regulates the proliferation of breast cancer cells – In vitro evidence‟, Drug Design, Development and Therapy, 9, pp. 5987–5999. doi: 10.2147/DDDT.S89390.
Bailly, C. and Vergoten, G. (2021) „Interaction of obtusilactone B and related butanolide lactones with the barrier-to-autointegration factor 1 (BAF1). A computational study‟, Current Research in Pharmacology and Drug Discovery, 2(August), pp. 1–8. doi: 10.1016/j.crphar.2021.100059.
Chau, L. Y. (2015) „Heme oxygenase-1: Emerging target of cancer therapy‟, Journal of Biomedical Science, 22(1), pp. 1–7. doi: 10.1186/s12929-015-0128-0.
Dewi Harnis, A. P. et al. (2020) „Virtual Inhibition Analysis of Bioactive Compound Brazilin (Caesalpinia sappan L.) Toward Progesterone Receptor or Lonaprisan in Breast Cancer Proliferation‟, Biotropika: Journal of Tropical Biology, 8(2), pp. 62–70. doi: 10.21776/ub.biotropika.2020.008.02.01.
Global Cancer Observatory (2020) „Cancer Incident in Indonesia‟, International Agency for Research on Cancer, 858, pp. 1–2.
Gorjánácz, M. (2014) „Nuclear assembly as a target for anti-cancer therapies‟, Nucleus (United States). doi: 10.4161/nucl.27928.
Handayani, S. et al. (2016) „Brazilein in combination with cisplatin inhibit proliferation and migration on highly metastatic cancer cells, 4T1‟, core.ac.uk, 21(1), pp. 38–47. Available at: https://core.ac.uk/download/pdf/298144682.pdf (Accessed: 9 December 2021).
Hanif, N., Hermawan, A. and Meiyanto, E. (2019) „Caesalpinia sappan L. Ethanolic Extract Decrease Intracellular ROS Level and Senescence of 4T1 Breast Cancer Cells‟, Indonesian Journal of Cancer Chemoprevention, 10(1), p. 16. doi: 10.14499/indonesianjcanchemoprev10iss1pp16-23.
Haryanti, S., Pramono, S., Murwanti, R., Meiyanto, E., Large Research and Development of Medicinal Plants and Traditional Medicine, B., & Health of the Republic of Indonesia, K. (2016). The synergistic effect of doxorubicin and ethanolic extracts of Caesalpinia sappan L. wood and Ficus septica Burm. f. leaves on viability, cell cycle progression.Indonesian Journal of Biotechnology, 21(1), 29–37. doi: 10.22435/hsji.v9i1.486.
Haryanti, S., Widiyastuti, Y. and Rahmawati, N. (2018) „Cytotoxic and MMPs inhibitory activities of Sappan Wood (Caesalpiniasappan L.): various extracts on 4T1 breast cancer cell line‟, Health Science Journal of Indonesia, 9(1), pp. 51–56. doi: 10.22435/hsji.v9i1.483.
Horneber, M. et al. (2012) „How many cancer patients use complementary and alternative medicine: A systematic review and metaanalysis‟, Integrative Cancer Therapies, 11(3), pp. 187–203. doi: 10.1177/1534735411423920.
Hung, T. M. et al. (2013) „Cytotoxic activity of new phenolic compounds from vietnamese caesalpinia sappan‟, Bioscience, Biotechnology and Biochemistry, 77(12), pp. 2378–2382. doi: 10.1271/BBB.130493.
Hung, T. M., Dang, N. H. and Dat, N. T. (2014) „Methanol extract from Vietnamese Caesalpinia sappan induces apoptosis in HeLa cells‟, Biological Research, 47(1). doi: 10.1186/0717-6287-47-20/fulltext.html.
Husna , U. , Putu , N. , Laksmiani , L. , Susidarti , R. A. , & Meiyanto , E. (2017). Ethyl acetate fraction of Caesalpinia sappan L. enhances cisplatin‟s cytotoxicity on HeLa cells via G1 and S arrest through p53 expression.Indonesian Journal of Cancer Chemoprevention (IJCC), 8(2), 51–60.
Jang, H. Y., Hong, O. Y., Chung, E. Y., Park, K. H., & Kim, J. S. (2020). Roles of JNK / Nrf2 Pathway on Hemin-Induced Heme Activation, Oxygenase- Breast, Mcf- Human Cells. Medicine, 56(268), 1–11. Available at: https://www.mdpi.com/1648-9144/56/6/268 (Accessed: 9 December 2021).
Jenie, R. I. et al. (2017) „Cytotoxic and Antimetastasis Effect of Ethyl Acetate Fraction from Caesalpinia sappan L. on MCF-7/HER2 Cells‟, Indonesian Journal of Cancer Chemoprevention, 8(1), p. 42. doi: 10.14499/indonesianjcanchemoprev8iss1pp42-50.
Jenie, R. I. et al. (2018) „The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubicin on MCF-7/HER2 Cells.‟, Advanced pharmaceutical bulletin, 8(3), pp. 507–516. doi: 10.15171/apb.2018.059.
Khamsita, R. et al. (2012) „Ethanolic extract of Secang (Caesalpinia sappan L.) wood performs as chemosensitizing agent through apoptotic induction on breast cancer MCF-7 Cells‟, ijcc.chemoprev.org. Available at: http://ijcc.chemoprev.org/index.php/ijcc/article/view/69 (Accessed: 8 December 2021).
Kim, B. et al. (2012) „Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells.‟, Journal of agricultural and food chemistry, 60(39), pp. 9882–9889. doi: 10.1021/jf302527p.
Kim, S.-H. et al. (2016) „Brazilin isolated from Caesalpinia. sappan suppresses nuclear envelope reassembly by inhibiting BAF phosphorylation‟, Citeseer, 352, pp. 175–184. doi: 10.1124/jpet.114.218792.
Kim, S. H. et al. (2012) „Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells‟, Journal of Agricultural and Food Chemistry, 60(39), pp. 9882–9889. doi: 10.1021/JF302527P.
Kwak, A.-W. et al. (2021) „The 3-deoxysappanchalcone induces ROS-mediated apoptosis and cell cycle arrest via JNK/p38 MAPKs signaling pathway in human esophageal cancer cells‟, Phytomedicine, 86, p. 153564. doi: https://doi.org/10.1016/j.phymed.2021.153564.
Lee, D. et al. (2013) „Brazilin inhibits growth and induces apoptosis in human glioblastoma cells‟, mdpi.com. Available at: https://www.mdpi.com/47386 (Accessed: 9 December 2021).
Lee, Y. et al. (2011) „Mechanism of sappanchalcone-induced growth inhibition and apoptosis in human oral cancer cells‟, Elsevier. Available at: https://www.sciencedirect.com/science/article/pii/S0887233311002517 (Accessed: 14 March 2022).
Ngernnak, C., Panyajai, P. and Anuchapreeda, S. (2018) „Phytochemical and cytotoxic investigations of the heartwood of Caesalpinia sappan linn‟. Available at: http://cmuir.cmu.ac.th/handle/6653943832/58994 (Accessed: 8 December 2021).
Nurzijah, I. et al. (2012) „Secang (Caesalpinia sappan L.) Heartwood Ethanolic Extract Shows Activity as Doxorubicin Co-chemotherapeutic Agent by Apoptotis Induction on T47D Breast‟, ijcc.chemoprev.org. Available at: https://www.ijcc.chemoprev.org/index.php/ijcc/article/view/59 (Accessed: 8 December 2021).
Pratiwi, S. R., Widianti, E. and Solehati, T. (2017) „Gambaran Faktor-Faktor yang Berhubungan dengan Kecemasan Pasien Kanker Payudara dalam Menjalani Kemoterapi‟, Jurnal Pendidikan Keperawatan Indonesia, 3(2), p. 167. doi: 10.17509/jpki.v3i2.9422.
Purwaningsih, E. (2014) „Pemendekan Telomer Dan Apoptosis Telomere Shorthening And Apoptosis‟, Jurnal Kedokteran Yarsi, 22(2), pp. 132–141.
Rachmady, Rahmawaty et al. (2017) „Antiproliferative effect of secang heartwood ethanolic extract (Caesalpinia sappan L.) on HER2-positive breast cancer cells‟, Indonesian Journal of Cancer Chemoprevention (IJCC), 7(1). Available at: http://ijcc.chemoprev.org/index.php/ijcc/article/view/95 (Accessed: 8 December 2021).
Ratnasari, A. A. et al. (2016) „Hubungan Ekspresi NFκB dengan Respons Radiasi Kanker Serviks Stadium Lokal Lanjut‟, eJournal Kedokteran Indonesia, 4(1). doi: 10.23886/ejki.4.5906.31-6.
Riris Istighfari Jenie, Sri Handayani, Ratna Asmah Susidarti, Linar Zalinar Udin, E. M. (2018). The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubici.pdf.Advanced Pharmaceutical Bulletin, 8(3), 507–516.
Rivanti, E., Shabrina, B., Nurzijah, I., … C. A.-… J. of C., & 2016, U. (2017). Heartwood of Sappan (Caesalpinia sappan L.) ethanolic extract show selective cytotoxic activities on T47D and Widr cells but not on Hela Cells. Indonesian Journal of Cancer Chemoprevention (IJCC), 7(2), 60–67.
Robinson, T. (1995). Organic Content of High Plants Ed.6. In Kosasih Padmawinata (Ed.),ITB-press (Edition 6).
Sarmoko, L. and (2012) Regulasi Siklus Sel, Cancer Chemoprevention Research Center Universitas Gadjah Mada. Available at: https://ccrc.farmasi.ugm.ac.id/?p=2584.
Tao, L., Li, J. and And, J. Z. (2011) „Brazilein overcame ABCB1-mediated multidrug resistance in human leukaemia K562/AO2 cells‟, African Journal of Pharmacy and Pharmacology, 5(16). doi: 10.5897/AJPP11.099.
Tao, L., Li, J. and Zhang, J. (2013) „Brazilein, a compound isolated from Caesalpinia sappan Linn., induced growth inhibition in breast cancer cells via involvement of GSK-3β/β-Catenin/cyclin D1 pathway.‟, Chemico-biological interactions, 206(1), pp. 1–5. doi: 10.1016/j.cbi.2013.07.015.
Tirtanirmala, P. et al. (2015) „Cytotoxic and apoptotic-inducing effect of fraction containing Brazilein from Caesalpinia sappan L. and cisplatin on T47D cell lines‟, Indonesian Journal of Cancer Chemoprevention (IJCC), 6(3), pp. 89–96. Available at: https://iscc-indonesia.org/chemoprev.org/ijcc/index.php/ijcc/article/view/91 (Accessed: 8 December 2021).
Utami, D. T. et al. (2020) „Co-treatment of Brazilein Enhances Cytotoxicity of Doxorubicin on WiDr Colorectal Cancer Cells Through Cell Cycle Arrest‟, Indonesian Biomedical Journal, 12(4), pp. 376–382. doi: 10.18585/INABJ.V12I4.1293.
Utomo, R. Y. et al. (2018) „Enhancement of cytotoxicity and apoptosis induction of Doxorubicin by Brazilein containing fraction of secang (Caesalpinia sappan L.) on T47D Cells‟, Indonesian Journal of Cancer Chemoprevention (IJCC), 9(1), 32–40. Available at: https://iscc-indonesia.org/chemoprev.org/ijcc/index.php/ijcc/article/view/208 (Accessed: 9 December 2021
Published
2022-12-05
How to Cite
MUTIAH, Roihatul; FATHIN, Fita Faniya.
Systematic Literature Review Potential of Sappan Wood Plants (Caesalpinia sappan L.) As Anticancer.
Proceeding Annual Symposium on Hajj and Umrah Medicine, [S.l.], v. 1, p. 122-148, dec. 2022.
ISSN 2987-548X.
Available at: <http://conferences.uin-malang.ac.id/index.php/anshar/article/view/2140>. Date accessed: 04 may 2024.
doi: https://doi.org/10.18860/anshar.v1i0.2140.
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