Formulation and Characterization of SNEDDS of Dayak Onion Extract with Comparative Variations of Surfactants, Co-Surfactants, and Palm Oil

Abstract

Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a thermodynamically stable drug administration unit with the capacity to increase the solubility of active pharmaceutical ingredients (API) and bioavailability. In addition, dayak onion extract is an active ingredient developed to increase the effectiveness of therapy. The aims to formulate, characterize, and investigate stability. Moreover, the HLB approach was used to formulate SNEDDS from dayak onion extract, with a component ratio of palm oil, a combination of surfactants (hydrophilic Tween 80, Tween 20) and lipophilic (Span 20 and Transcutol) and PEG 400 as co-surfactants. A total of sixty formulas were used, with an HLB range of 11-15 and a ratio of 1:8:1, 1:7:2, and 2:7:1, followed by evaluating product characteristics. Furthermore, two formulas were selected, including F13 (HLB 13) and F34 (HLB 14), at ratios 1:8:1 and 1:7:2. The results showed particle size ranging from 10-200 nm, percent transmittance of <90%, while the viscosity and pH values were stable at various dilutions. The evaluation for thermodynamics indicates an unstable preparation. Therefore, the SNEDDS formula of dayak onion extract using long-chain triglycerides (palm oil) was ineffective.

Author Biographies

Rahmi Annisa, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

Alif Firman Firdausy, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

Ihda Mahila Alawiyah, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

Farianda Reformasiska, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

References

Annisa, Rahmi., EstiHendradi., dan DewiMelani. 2016. Pengembangan Sistem Nanostructured Lipid Carriers (NLC) Meloxicam Dengan Lipid Monostearin Dan Miglyol 808 Menggunakan Metode Emulsifikasi. J. Trop. Pharm. Chem. Vol 3. No. 3.
Astuti, IkaYuni, Marchaban, Ronny Martien, dan Agung Endro Nugroho. 2018. Physical Characterization and Dissolution Study of Pentagamavunon-0 Loaded Self Nano-Emulsifying Drug Delivery System. Indonesian J. Pharm. 29(2), 6.
Basalious., Emad B., Nevine S., dan Shaimaa M. Badr-Eldin. 2010. SNEDDS Containing Bioenhanchers for Improvement of Dissolution and Oral Absorption of Lacidipine. I: Development and Optimization. International Journal of Pharmaceutics. No. 391, Hal: 203-211.
Date, A.A., Desai, N., Dixit, R., dan Nagarsenker, M. 2010. Selfnanoemulsifyingdrug delivery systems: formulation insights, applications, and advances. Nanomedicine. 5: 1595–1616.
Debnath, S., Satayanarayana, dan Kumar, G.V. 2011. Nanoemulsion-A Method to Improve The Solubility of Lipophilic Drugs. Int. J. Adv. Pharm. Sci., 2: 72–83.
Huda, Nurul dan iisWahyuningsih., 2016. Karakterisasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) MinyakBuah Merah (Pandanus conoideus Lam.). JurnalFarmasi dan IlmuKefarmasian Indonesia. Vol. 3(2).
Jusnita , Nina, dan KhairunnisaNasution. 2019. FormulasiNanoemulsiEkstrakDaunKelor (Moringa oleifera Lamk). JurnalTeknologi dan Manajemen Agroindustri. Volume 8 Nomor 3: 165-170.
Komaiko, J., dan McClements, D.J. 2015. Food-grade nanoemulsion filled hydrogels formed by spontaneous emulsification and gelation: optical properties, rheology, and stability, Food Hydrocolloid., 46, 67–75.
Marpaung YG. 2014. FormulasiNanoemulsiMinyakSawitdengan High PressureHomogenizer. [Skripsi]. Bogor (ID): InstitutPertanian Bogor.
Martien, Ronny,. Adhyatmika,. Iramie D. K. Irianto,. Verda Farida,. Dian Purwita Sari. 2012. PerkembanganTeknologiNanopartikelSebagaiSistemPenghantaranObat. MajalahFarmaseutik. Vol. 8 (1).
Nasr, A., Gardouh, A., &Ghorab, M. 2016. Novel Solid Self-Nanoemulsifying Drug Delivery System(S-SNEDDS) for Oral Delivery of Olmesartan Medoxomil: Design, Formulation, Pharmacokinetic and Bioavailability Evaluation. MDPI.Pharmaceutics Journal. 8(20):1-29.
Nurdianti, L & Rahmiyanti, I. 2016. Uji AktivitasAntioksidanKrimEkstrakDaun Mangga (Mangifera indica L) Terhadap DPPH (1,1-diphenyl-2- picrylhydrazil). Jurnal Kesehatan Bakti Tunas Husada. 16 (1).
Nurdianti, L & Rahmiyanti, I. 2016. Uji AktivitasAntioksidanKrimEkstrakDaun Mangga (Mangifera indica L) Terhadap DPPH (1,1-diphenyl-2- picrylhydrazil). Jurnal Kesehatan Bakti Tunas Husada. 16
Pratiwi, Liza dkk. 2018. Uji StabilitasFisik dan Kimia Sediaan SNEDDS (Self-nanoemulsifying Drug Delivery System) dan NanoemulsiFraksiEtilAsetatKulit Manggis (Garcinia mangostana L.). Traditional Medicine Journal. Vol. 23(2).
Ren, F., Qiufang, J., Jingbin, C., Jianming, C., Yongjia, S. 2009. Self-Nanoemulsifying Drug Delivery System (SNEDDS) of Anethole Trithione by Combined Use of Surfactants Journal of Dispersion Science and Technology. Vol. 30, Hal: 580-586.
Sahumena, M. H. (2014). PengembanganNanopartikel Ketoprofen dengan Teknik SNEDDS dan Uji AktifitasAntiinflamasi. Tesis Program PascaSarjana; Universitas Gadjah Mada, Yogyakarta.
Sapra, K., Sapra, A., Singh, S.K., dan Kakkar, S. 2012. Self emulsifying drug delivery system: A tool in solubility enhancement of poorly soluble drugs. Indo global journal of pharmaceutical science., 2: 313–332.
Shafiq-un-Nabi, S., Shakeel, F., Talegaonkar, S., Ali, J., Baboota, S., Ahuja, A., dkk. 2007. Formulation development and optimization using nanoemulsion technique: a technical note. AAPS pharmscitech. 8: E12–E17.
Syukri Y., HannieFitriani., HeriantoPandapotan., dan bambangHernawan Nugroho. 2019. Formulation, Characterization, and Stability of Ibuprofen-Loaded Self-Nano Emulsifying Drug Delivery System(SNEDDS). Indonesian Journal of Pharmacy. Vol. 30 (2) 2019: 105 – 113.
Syukri Y., Martien R., Lukitaningsih E. and Nugroho A. E. 2018. Novel Self-Nano Emulsifying Drug Delivery System (SNEDDS) of andrographolide isolated from Andrographis paniculataNees: Characterization, in-vitro and in-vivo assessment. Journal of Drug Delivery Science and Technology, 47, 514–520.
Syukri, Y., Agung, E.N., Ronny, M., dan Endang, L. 2016. ValidasiPenetapan Kadar IsolatAndrografoliddariTanamanSambiloto (Andrographis paniculataNees) Menggunakan HPLC. J. SainsFarmasi dan Klinis.Vol. 2, No.4, Hal: 8-14.
Winarti, Lina., Suwaldi, Ronny Martien, dan Lukman Hakim. 2016. Formulation Of Self-Nanoemulsifying Drug Delivery System Of Bovine Serum Albumin Using Hlb (Hydrophilic-Lypophilic Balance) Approach. Indonesian J. Pharm. Vol. 27. No. 3 : 117 – 127.
Wirnarti, Suwaldi, Matin, Hakim. 2018. Formulation of Insulin Self Nanoemulsifying Drug Delivery System and Its In Vitro-In Vivo Study. Indonesian J. Pharm. Vol. 29, No. 3, Hal: 158-166.
Zhao, T., Maniglio, D., Chen, J., Chen, B., Motta, A., Migliaresi, C. 2015. Design and optimization of Self-NanoemulsifyingFormulations for Lipophilic Drugs. Nanotechnology. No. 26, Hal:125-130.
Published
2021-12-05
How to Cite
ANNISA, Rahmi et al. Formulation and Characterization of SNEDDS of Dayak Onion Extract with Comparative Variations of Surfactants, Co-Surfactants, and Palm Oil. Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR), [S.l.], v. 1, p. 15-25, dec. 2021. ISSN 2827-7848. Available at: <http://conferences.uin-malang.ac.id/index.php/planar/article/view/1455>. Date accessed: 19 aug. 2022. doi: https://doi.org/10.18860/planar.v1i0.1455.