Phytochemical and Pharmacology Effect of Calotropis gigantea as Anti-Cancer Therapy: Systematic Review

Abstract

The high prevalence of cancer in the world makes many researchers look for alternative therapies that can be used to treat cancer. One of them is by using traditional plants, namely Calotropis gigantea R.Br. This is due to alkaloids, glycosides, and tannins in plants that function as anticancer. The purpose of this study was to dig deeper into information related to the phytochemistry and pharmacology effect of Calotropis gigantea as an anticancer therapy and can be used as a reference for the development of traditional medicines. The method used is PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses), with inclusion and exclusion criteria, 11 articles were selected for review. The results showed that Calotropis Gigantea contains Calotropin, Calotroposide A, oxypregnane oligoglycoside compounds, which inhibit cancer cell growth through the mechanism of apoptosis induction and ROS inhibition. From this systematic review, it can be recommended that the plant Calotropis gigantea can be further developed into standardized herbal medicine and phytopharmaceuticals.

Author Biographies

Roihatul Mutiah, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

Humaira Ramzi, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

Jesi Aulia Bustami, Universitas Islam Negeri Maulana Malik Ibrahim

Department of Pharmacy, Faculty of Medical and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, Indonesia

References

Padhi, S. (2019). Phytochemical Screening And Anticancer Activity Of Calotropis Gigantea ( L .) Dryand . Leaf Extract. August 2021.
Rahman, M. G. and P. K. S. M. (2015). Medicinal Plants: Their Use in Anticancer Treatment. Int J Pharm Sci Res., 6(10), 4103–4112. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12.Medicinal
Sarkar, S., Chakraverty, R., & Diseases, E. (2015). Calotropis Gigantea Linn . - A Complete Busket Of Indian Traditional Medicine Calotropis Gigantea Linn . - A Complete Busket Of Indian Traditional Medicine. April.
Deshmukh, P. T., Fernandes, J., Atul, A., & Toppo, E. (2009). Wound healing activity of Calotropis gigantea root bark in rats. 125, 178–181. https://doi.org/10.1016/j.jep.2009.06.007
Fitriatuzzakiyah,.dkk.2017. Terapi Kanker dengan Radiasi: Konsep Dasar Radioterapi dan Perkembangannya di Indonesia. Jurnal Farmasi Klinik Indonesia. Vol.6 No4
Kumar, G., Karthik, L., Venkata, K., & Rao, B. (2010). Antibacterial activity of aqueous extract of Calotropis gigantea leaves - An in vitro study. September.
Kumar, G., Loganathan, K., & Rao, B. (2010). In vitro anti-Candida activity of Calotropis gigantea Available online through. January.
Marphirah, 2018. Pemberian salep Ekstrak Bunga Biduri (Calotropis gigantea) untuk Penyembuhan Luka Pada Mencit (Mus muscullus) Secara Klinis dan histopatologis. Vol. 6 No. 2
Patil, S. M., & Saini, R. (2012). Antimicrobial Activity of Flower Extracts of Calotropis Gigantea. 1(4), 142–145.
Sarkar, S., Chakraverty, R., & Diseases, E. (2015). Calotropis Gigantea Linn . - A Complete Busket Of Indian Traditional Medicine Calotropis Gigantea Linn . - A Complete Busket Of Indian Traditional Medicine. April.
Ulfa.2021.Inventarisasi Keanekaragaman Tumbuhan Obat di Kecamatan Medan Tembung Kota Medan Propinsi Sumatera Utara. BEST Journal (Biology Education, Sains and Technology) Vol. 4 No.1
Wang Z.,et al. 2008. A new cytotoxic pregnanone from calotripis gigantea . Molecules. Vol 13, No.12
Avinash et al, 2019. Phytochemical screening and anticancer activity of Calotropis gigantea (L.) Dryand. leaf extract. International Journal of Scientific Research and Review. Volume 07, Issue 05, May 2019
Mutiah, et al. 2018. Calotroposid A: a Glycosides Terpenoids from Calotropis gigantea Induces Apoptosis of Colon Cancer WiDr Cells through Cell Cycle Arrest G2/M and Caspase 8 Expression. Asian Pacific Journal of Cancer Prevention, Vol. 19 No. 6
Zhou et al, 2019. Calotropin activates YAP through downregulation of LATS1 in colorectal cancer cells. OncoTargets and Therapy Vol. 19 hal 4047–4054
Pederson et al , 2020. Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. J Nat Prod. Vol. 7 No. 83
Lee, 2019. Calotropis gigantea extract induces apoptosis through extrinsic/intrinsic pathways and reactive oxygen species generation in A549 and NCI-H1299 non-small cell lung cancer cells. Lee et al. BMC Complementary and Alternative Medicine. Vol. 19 No. 34
Mahar et al , 2016. Bioactivity guided isolation of oxypregnane-oligoglycosides (Calotroposides) from the root bark of Calotropis gigantea as potent anticancer agents. J. Name Vol. 1 No. 3
Amutha et al, 2020. Phytochemical Analysis Of Calotropis Gigantea (LINN) And It's Biolohical Activities. World Journal of Pharmaceutical Research. Vol. 9 No. 6
Thanwarat et al, 2021. Calotropis gigantea stem bark extract induced apoptosis related to ROS and ATP production in colon cancer cells. Plos One. Malaysia : AIMST University
Mutiah, dkk , 2016.The Marker Active Compound Identification of Calotropis gigantea Roots Extract as an Anticancer. Japan ; ICBPPT Kyoto
Immaculate.,et al 2020.Anticancer and antioxidant activity of silver nanoparticles of calotropis gigantea. Annals of R.S.C.B., Vol. 24, No. 1,
Mutiah, dkk 2016. Comparison of Ethanol Extract from Roots, Leaves, and Flowers of Calotropis gigantea as Anticancer on T47D Breast Cancer Cell Lines. ALCHEMY Journal of Chemistry. Vol. 5 No. 1
Published
2021-12-05
How to Cite
MUTIAH, Roihatul; RAMZI, Humaira; BUSTAMI, Jesi Aulia. Phytochemical and Pharmacology Effect of Calotropis gigantea as Anti-Cancer Therapy: Systematic Review. Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR), [S.l.], v. 1, p. 42-48, dec. 2021. ISSN 2827-7848. Available at: <http://conferences.uin-malang.ac.id/index.php/planar/article/view/1458>. Date accessed: 19 aug. 2022. doi: https://doi.org/10.18860/planar.v1i0.1458.