Systematic Review: Potential of Curcumin Compounds as Immunostimulants in the Prevention of SARS-CoV 2 Virus
Abstract
Curcumin is a compound from the turmeric rhizome plant (Curcuma longa), which has immunostimulating activity. This activity has been tested pre-clinically in vitro, in vivo, and in silico. It can be used as raw material for drugs in the development of new drugs to prevent the SARS-CoV 2 virus. The purpose of this study was to examine the immunostimulatory activity of turmeric in vitro, in vivo, and in silico and to explore the mechanism of curcumin compounds as immunostimulants. The method used in this systematic review is Systematic-Meta Analysis by identifying articles from several journal databases (Google Scholar, ResearchGate, ScienceDirect, and Garuda Dikti). Furthermore, the article selection process used a PRISMA guideline flow chart. This process found 15 articles as the main reference, five articles containing in vitro research, five in vivo, and five in silico from the turmeric rhizome plant. In vitro, preclinical tests show that curcumin compounds have an immunostimulating effect characterized by the occurrence of proliferation and activation in several types of immune system cells. In vivo study was proven by increased phagocytic activity and increased leukocyte production in experimental animals. Whereas in silico was demonstrated by the binding of various SARS-CoV 2 receptors.
References
[1] Afolayan, F. I. D., Erinwusi, B., & Oyeyemi, O. T. 2018. Immunomodulatory activity of curcumin-entrapped poly d,l-lactic-co-glycolic acid nanoparticles in mice. Integrative Medicine Research, 7(2), 168–175.
[2] Antoine, F., Simard, J. C., & Girard, D. 2013. Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo. International Immunopharmacology, 17(4), 1101–1107.
[3] Arisonya, S., Wibisono, G., & Grahita, A. 2014. Efektivitas Ekstrak Kunyit (Curcuma Domestica) Terhadap Jumlah Sel Makrofag dan Diameter pada Lesi Ulkus Traumatikus. Jurnal B-Dent, 1(2), 118–125.
[4] Badan Nasional Penanggulangan Bencana. [Online].; 2021 [cited 2021 April 25 Available from: https://bnpb.go.id/.
[5] Behera, T., Swain, P., Sahoo, S. K., Mohapatra, D., & Das, B. K. 2011. Immunostimulatory effects of curcumin in fish, Labeo rohita (H.). Indian Journal of Natural Products and Resources, 2(2), 184–188.
[6] Chandrasekaran, C., Sundarajan, K., Edwin, J., Gururaja, G., Mundkinajeddu, D., & Agarwal, A. 2013. Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction. Pharmacognosy Research, 5(2), 71–79.
[7] Diab, A. M., Saker, O. A., Eldakroury, M. F., & Elseify, M. M. 2014. Effects of garlic (Allium sativum) and curcumin (Turmeric, Curcuma longa Linn) on Nile tilapia immunity. Vet Med J Giza, 60(April), C1–C19.
[8] Elgendy, M. Y., Hakim, A. S., Ibrahim, T. B., Soliman, W. S., & Ali, S. E. 2016. Immunomodulatory effects of curcumin on Nile tilapia, Oreochromis niloticus and its antimicrobial properties against vibrio alginolyticus. Journal of Fisheries and Aquatic Science, 11(3), 206–215.
[9] Gil, C., Ginex, T., Maestro, I., Nozal, V., Barrado-Gil, L., Cuesta-Geijo, M. Á., ... & Martinez, A. 2020. COVID-19: Drug Targets and Potential Treatments. Journal of medicinal chemistry, 63(21), 12359-12386.
[10] Gupta, S., Singh, A. K., Kushwaha, P. P., Prajapati, K. S., Shuaib, M., Senapati, S., & Kumar, S. 2020. Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies. Journal of Biomolecular Structure and Dynamics, 1102.
[11] Gurevitch, J., Koricheva, J., Nakagawa, S., & Stewart, G. 2018. Meta-analysis and the science of research synthesis. Nature, 555(7695), 175–182.
[12] Hidayah, N., Puspita, R., & Mujahidah, M. 2020. Pengaruh Ekstrak Kunyit (Curcuma domestica Val) Terhadap Berat Badan, Jumlah Eosinofil dan Basofil Ayam Petelur yang Diinfeksi Salmonella pullorum. Jurnal Medik Veteriner, 3(2), 230.
[13] Laksmiani, N. P., Febryana Larasanty, L. P., Jaya Santika, A. A. G., Andika Prayoga, P. A., Kharisma Dewi, A. A. I., & Kristiara Dewi, N. P. A. 2020. Active compounds activity from the medicinal plants against SARS-CoV-2 using in silico assay. Biomedical and Pharmacology Journal, 13(2), 873–881.
[14] Li, M., Yue, G. G. L., Tsui, S. K. W., Fung, K. P., & Lau, C. B. S. 2018. Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. Phytomedicine, 46, 131–141.
[15] Manurung, U. N., & Mose N. 2019. Pemanfaatan kunyit (Curcuma domestica Val) sebagai imunostimulan pada ikan bawal (Colossoma macropomum). Budidaya Perairan, 7(1), 21–25.
[16] Mounce, B. C., Cesaro, T., Carrau, L., Vallet, T., & Vignuzzi, M. 2017. Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding. Antiviral Research, 142, 148–157.
[17] Mulatsari, E., Martati, T., Mumpuni, E., & Dewi, N. L. 2020. In Silico Analysis of Antiviral Activity of Analog Curcumin Compounds. Jurnal Jamu Indonesia, 5(3), 114–121.
[18] Pradani, T. C., Manampiring, A. E., Kepel, B. J., Budiarso, F. D., & Bodhi, W. 2021. Molecular Docking Terhadap Senyawa Kurkumin dan Arturmeron pada Tumbuhan Kunyit (Curcuma Longa Linn.) yang Berpotensi Menghambat Virus Corona. 9(2), 208–214.
[19] Priyadarsini, K. I. 2014. The Chemistry of Curcumin: from Extraction to Therapeutic Agent. Molecules, 19(12), 20091-20112.
[20] Rahman, D. R., Rimbawan, R., Madanijah, S., & Purwaningsih, S. 2017. Potensi selada air (Nasturtium officinale R. Br) sebagai antioksidan dan agen anti proliferasi terhadap sel MCF-7 secara in vitro. Jurnal Gizi Dan Pangan, 12(3), 217–224.
[21] Rajagopal, K., Varakumar, P., Baliwada, A., & Byran, G. 2020. Activity of Phytochemical Constituents of Curcuma longa and Andropraphis paniculata against coronavirus (COVID-19) an in silico Approach. Future Journal of Pharmaceutical Sciences, 6(104), 1–10.
[22] Selcuk, A. A. 2019. A Guide for Systematic Reviews: PRISMA. Turkish Archives of Otorhinolaryngology, 57(1), 57–58.
[23] Sengupta, M., Sharma, G. D., & Chakraborty, B. 2011. Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pacific Journal of Tropical Biomedicine, 1(3), 193–199.
[24] Snyder, H. 2019. Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104(July), 333–339.
[25] Subositi, D., & Wahyono, S. 2019. Study of the genus curcuma in Indonesia used as traditional herbal medicines. Biodiversitas, 20(5), 1356–1361.
[26] Sundari, R. 2016. Pemanfaatan dan Efisiensi Kurkumin Kunyit (Curcuma domestica) sebagai Indikator Titrasi Asam Basa. Teknoin, 22(8), 595–601.
[27] Tsatsakis, A., Calina, D., Falzone, L., Petrakis, D., Mitrut, R., Siokas, V., Pennisi, M., Lanza, G., Libra, M., Doukas, S. G., Doukas, P. G., Kavali, L., Bukhari, A., Gadiparthi, C., Vageli, D. P., Kofteridis, D. P., Spandidos, D. A., Paoliello, M. M. B., Aschner, M., & Docea, A. O. 2020. SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19. Food and Chemical Toxicology, 146(September), 111769.
[2] Antoine, F., Simard, J. C., & Girard, D. 2013. Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo. International Immunopharmacology, 17(4), 1101–1107.
[3] Arisonya, S., Wibisono, G., & Grahita, A. 2014. Efektivitas Ekstrak Kunyit (Curcuma Domestica) Terhadap Jumlah Sel Makrofag dan Diameter pada Lesi Ulkus Traumatikus. Jurnal B-Dent, 1(2), 118–125.
[4] Badan Nasional Penanggulangan Bencana. [Online].; 2021 [cited 2021 April 25 Available from: https://bnpb.go.id/.
[5] Behera, T., Swain, P., Sahoo, S. K., Mohapatra, D., & Das, B. K. 2011. Immunostimulatory effects of curcumin in fish, Labeo rohita (H.). Indian Journal of Natural Products and Resources, 2(2), 184–188.
[6] Chandrasekaran, C., Sundarajan, K., Edwin, J., Gururaja, G., Mundkinajeddu, D., & Agarwal, A. 2013. Immune-stimulatory and anti-inflammatory activities of Curcuma longa extract and its polysaccharide fraction. Pharmacognosy Research, 5(2), 71–79.
[7] Diab, A. M., Saker, O. A., Eldakroury, M. F., & Elseify, M. M. 2014. Effects of garlic (Allium sativum) and curcumin (Turmeric, Curcuma longa Linn) on Nile tilapia immunity. Vet Med J Giza, 60(April), C1–C19.
[8] Elgendy, M. Y., Hakim, A. S., Ibrahim, T. B., Soliman, W. S., & Ali, S. E. 2016. Immunomodulatory effects of curcumin on Nile tilapia, Oreochromis niloticus and its antimicrobial properties against vibrio alginolyticus. Journal of Fisheries and Aquatic Science, 11(3), 206–215.
[9] Gil, C., Ginex, T., Maestro, I., Nozal, V., Barrado-Gil, L., Cuesta-Geijo, M. Á., ... & Martinez, A. 2020. COVID-19: Drug Targets and Potential Treatments. Journal of medicinal chemistry, 63(21), 12359-12386.
[10] Gupta, S., Singh, A. K., Kushwaha, P. P., Prajapati, K. S., Shuaib, M., Senapati, S., & Kumar, S. 2020. Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies. Journal of Biomolecular Structure and Dynamics, 1102.
[11] Gurevitch, J., Koricheva, J., Nakagawa, S., & Stewart, G. 2018. Meta-analysis and the science of research synthesis. Nature, 555(7695), 175–182.
[12] Hidayah, N., Puspita, R., & Mujahidah, M. 2020. Pengaruh Ekstrak Kunyit (Curcuma domestica Val) Terhadap Berat Badan, Jumlah Eosinofil dan Basofil Ayam Petelur yang Diinfeksi Salmonella pullorum. Jurnal Medik Veteriner, 3(2), 230.
[13] Laksmiani, N. P., Febryana Larasanty, L. P., Jaya Santika, A. A. G., Andika Prayoga, P. A., Kharisma Dewi, A. A. I., & Kristiara Dewi, N. P. A. 2020. Active compounds activity from the medicinal plants against SARS-CoV-2 using in silico assay. Biomedical and Pharmacology Journal, 13(2), 873–881.
[14] Li, M., Yue, G. G. L., Tsui, S. K. W., Fung, K. P., & Lau, C. B. S. 2018. Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. Phytomedicine, 46, 131–141.
[15] Manurung, U. N., & Mose N. 2019. Pemanfaatan kunyit (Curcuma domestica Val) sebagai imunostimulan pada ikan bawal (Colossoma macropomum). Budidaya Perairan, 7(1), 21–25.
[16] Mounce, B. C., Cesaro, T., Carrau, L., Vallet, T., & Vignuzzi, M. 2017. Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding. Antiviral Research, 142, 148–157.
[17] Mulatsari, E., Martati, T., Mumpuni, E., & Dewi, N. L. 2020. In Silico Analysis of Antiviral Activity of Analog Curcumin Compounds. Jurnal Jamu Indonesia, 5(3), 114–121.
[18] Pradani, T. C., Manampiring, A. E., Kepel, B. J., Budiarso, F. D., & Bodhi, W. 2021. Molecular Docking Terhadap Senyawa Kurkumin dan Arturmeron pada Tumbuhan Kunyit (Curcuma Longa Linn.) yang Berpotensi Menghambat Virus Corona. 9(2), 208–214.
[19] Priyadarsini, K. I. 2014. The Chemistry of Curcumin: from Extraction to Therapeutic Agent. Molecules, 19(12), 20091-20112.
[20] Rahman, D. R., Rimbawan, R., Madanijah, S., & Purwaningsih, S. 2017. Potensi selada air (Nasturtium officinale R. Br) sebagai antioksidan dan agen anti proliferasi terhadap sel MCF-7 secara in vitro. Jurnal Gizi Dan Pangan, 12(3), 217–224.
[21] Rajagopal, K., Varakumar, P., Baliwada, A., & Byran, G. 2020. Activity of Phytochemical Constituents of Curcuma longa and Andropraphis paniculata against coronavirus (COVID-19) an in silico Approach. Future Journal of Pharmaceutical Sciences, 6(104), 1–10.
[22] Selcuk, A. A. 2019. A Guide for Systematic Reviews: PRISMA. Turkish Archives of Otorhinolaryngology, 57(1), 57–58.
[23] Sengupta, M., Sharma, G. D., & Chakraborty, B. 2011. Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice. Asian Pacific Journal of Tropical Biomedicine, 1(3), 193–199.
[24] Snyder, H. 2019. Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104(July), 333–339.
[25] Subositi, D., & Wahyono, S. 2019. Study of the genus curcuma in Indonesia used as traditional herbal medicines. Biodiversitas, 20(5), 1356–1361.
[26] Sundari, R. 2016. Pemanfaatan dan Efisiensi Kurkumin Kunyit (Curcuma domestica) sebagai Indikator Titrasi Asam Basa. Teknoin, 22(8), 595–601.
[27] Tsatsakis, A., Calina, D., Falzone, L., Petrakis, D., Mitrut, R., Siokas, V., Pennisi, M., Lanza, G., Libra, M., Doukas, S. G., Doukas, P. G., Kavali, L., Bukhari, A., Gadiparthi, C., Vageli, D. P., Kofteridis, D. P., Spandidos, D. A., Paoliello, M. M. B., Aschner, M., & Docea, A. O. 2020. SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19. Food and Chemical Toxicology, 146(September), 111769.
Published
2021-12-05
How to Cite
MA’ARIF, Burhan et al.
Systematic Review: Potential of Curcumin Compounds as Immunostimulants in the Prevention of SARS-CoV 2 Virus.
Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR), [S.l.], v. 1, p. 49-60, dec. 2021.
ISSN 2827-7848.
Available at: <http://conferences.uin-malang.ac.id/index.php/planar/article/view/1459>. Date accessed: 20 apr. 2024.
doi: https://doi.org/10.18860/planar.v1i0.1459.
Issue
Section
Articles
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
