Formulation and Evaluation of Herbal Hydrogel Containing Ageratum conyzoides Leaves Ethanol Extracts

Annisa Kartika Sari; Ummu Afifah Azzahra; Tazkia Fauziatus Sa’adah; Yuliansa Nurista; Elisa Putri Jihan Amir; Hikmatul Hasanah

doi:10.18860/planar.v3i0.2467

Annisa Kartika Sari Universitas Muhammadiyah Surabaya http://orcid.org/0009-0008-0138-9050
Ummu Afifah Azzahra Universitas Muhammadiyah Surabaya
Tazkia Fauziatus Sa’adah Universitas Muhammadiyah Surabaya
Yuliansa Nurista Universitas Muhammadiyah Surabaya
Elisa Putri Jihan Amir Universitas Muhammadiyah Surabaya
Hikmatul Hasanah Universitas Muhammadiyah Surabaya http://orcid.org/0009-0001-8032-6937

DOI: https://doi.org/10.18860/planar.v3i0.2467

Abstract

Ageratum conyzoides Linn. can be used for wound healing. The main compound found in Ageratum leaves is 5'-methoxy nobiletin, a class of polymethoxyflavone that may treat pain and inflammation. The pharmaceutical preparation chosen for the development of Ageratum leaf as a wound-related pain relief is a hydrogel, because of its several advantages, namely, it is more convenient, practical, and forms a rinseable film layer that gives a cool feeling to the skin. This study intends to explore the impact of numerous concentrations of ethanol extract of Ageratum leaves on the physical evaluation of hydrogels. Hydrogel preparations were made with varying concentrations of Ageratum leaf ethanol extract 5%, 6%, and 7.5%. The resulting formula was physically assessed to ensure its quality. The assessment included organoleptic, homogeneity, degree of acidity, spreadability, viscosity, and FT-IR analysis. Statistical data processing of the physical quality of hydrogels was carried out using two-way analysis of variance (ANOVA) to test whether there was a significant difference between formulations. The results showed that all formulas were in accordance with the evaluation requirements including the organoleptic, homogeneity, acidity degree (pH), spreadability, viscosity, and FT-IR analysis. There was no significant change in the spreadability and pH of the formulations over 28 days. Based on the results of organoleptic tests, homogeneity, viscosity, acidity degree, spreadability, and FTIR analysis, it is known that all formulas achieved all physical requirements. This indicates that the hydrogel composed of carbomer 940 and hydroxypropyl methylcellulose can be an ideal base for ethanol extract of Ageratum leaves.

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