Network Pharmacology Analysis of Cananga odorata as a Treatment for Anxiety Disorders
Abstract
Anxiety disorder is a psychological disorder associated with the existence of mental disorders and experiencing constant anxiety. In C. odorata, part of the flower has the potential as a sedative for the nervous system and for dealing with anxiety. The study aims to analyze the potential compound content in Cananga odorata for treating anxiety disorders with In silico-based pharmacological network analysis. CO compound data from the KNApSAck database, Absorption, Distribution, Metabolism, and Excretion (ADME) screening using SwissADME, predicted target proteins using Swiss Target Prediction, GeneCards, Venny, String DB pharmacological network analysis, Visualization with Cytoscape version 3.10.0, and Way2drug. The results of the pharmacological tissue analysis of the compound content in C. odorata obtained 45 compounds, and 18 known active components meet the criteria of Absorption, Distribution, Metabolism, and Excretion (ADME) that correspond to the drug compounder (Drug Likeness/DL). Based on the pathway that correlates with anxiety disorder therapy are the neurotransmitter systems like serotonin receptors and dopamine receptors. The known therapeutic target proteins are HTR1A, HTR2A, SLC6A4, NR3C1, MAOA, DRD4, HSP90AA1, JUN, ten active compounds associated with C. odorata namely Anonaine, (+)-Reticuline, linalool, (-)-Coreximine, Micheline A, (-)-Ushinsunine beta-N-oxide, 4-Terpineol, alpha-Terpeneol, Sampangine, Anaxagoreine. Based on the results of research, C. odorata is potentially a treatment for anxiety disorder.
References
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Azizah, A. N. and Kurniati, C. H. (2020) ‘Obat Herbal Meredakan Batuk Pilek’, 2(3), p. 259–269.
Bousman, C. A. et al. (2023) ‘Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants’, Clinical Pharmacology and Therapeutics, 114(1), p. 51-68. doi: 10.1002/cpt.2903.
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Doncheva, N. T. et al. (2019) ‘Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data’, Journal of Proteome Research, 18(2), p. 623-632. doi: 10.1021/acs.jproteome.8b00702.
Fakih, T. M., Ramadhan, D. S. F. and Darusman, F. (2021) ‘In Silico Activity Identification of Cyclo Peptide Alkaloids from Zizyphus Spina-Christi Species Against Sars-Cov-2 Main Protease’, Jurnal Biodjati, 6(1), p. 71-81. doi: 10.15575/biodjati.v6i1.10603.
Fatmasari, F. H., Mukti, R. A. and Nuraini, I. (2023) ‘Uji Ketahanan pH Minyak Atsiri dari Kulit Buah Jeruk dan Bunga Kenanga sebagai Bahan Pengganti Aromaterapi pada Mata Kuliah Perawatan Badan’, Journal on Education, 5(3), p. 6353-6358. doi: 10.31004/joe.v5i3.1419.
Jannah, S. H. (2018) ‘Kawasan Hutan Olat Cabe Desa Batu Bangka Program Studi Pendidikan Biologi , FPMIPA , IKIP Mataram , Indonesia Bioscientist : Jurnal Ilmiah Biologi’, Jurnal Ilmiah Biologi, 6(2), p. 145-172.
Kim, K. et al. (2020) ‘Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor’, Cell, 182(6), p. 1574-1588. doi: 10.1016/j.cell.2020.08.024.
Liu, X. et al. (2021) ‘Mechanism of pharmacological effect of Angelica essential oil on anxiety based on network pharmacology and molecular docking’, Tropical Journal of Pharmaceutical Research, 20(4), p. 789-796. doi: 10.4314/tjpr.v20i4.19.
Makatita, F. A., Wardhani, R. and Nuraini (2020) ‘Riset in silico dalam pengembangan sains di bidang pendidikan, studi kasus: analisis potensi cendana sebagai agen anti-aging’, Jurnal ABDI, 2(1), p. 59-67.
Naufa, F., Mutiah, R. and Indrawijaya, Y. Y. A. (2022) ‘Studi in silico potensi senyawa katekin teh hijau (Camellia sinensis) sebagai antivirus SARS CoV-2 terhadap spike glycoprotein (6LZG) dan main protease (5R7Y)’, J.Food Pharm.Sci, 10(1), p. 584-596.
Nida, F. L. K. (2014) ‘Zikir Sebagai Psikoterapi Dalam Gangguan Kecemasan Bagi Lansia’, Jurnal Bimbingan Konseling Islam, 5(1), p. 133-150.
Noor, F. et al. (2022) ‘Network Pharmacology Approach for Medicinal Plants: Review and Assessment’, Pharmaceuticals, 1-33. doi: 10.3390/ph15050572.
Oktapiani, N. and Putri, A. (2018) ‘Rasional Emotif Terapi Gangguan Kecemasan Sosial dengan Menggunakan Pendekatan’, Fokus, 1(6), p. 227-232.
Piszczek, L. et al. (2015) ‘Modulation of anxiety by cortical serotonin 1A receptors’, Frontiers in Behavioral Neuroscience, 9, p. 1-10. doi: 10.3389/fnbeh.2015.00048.
Qiu, M. et al. (2021) ‘mRNA Levels of MAOA and 5-HT2A Receptor in Patients With Pathological Internet Use: Correlations With Comorbid Symptoms’, Frontiers in Psychiatry, 12, p. 1-8. doi: 10.3389/fpsyt.2021.667699.
Rahma, P. A. Y. et al. (2020) ‘Analisis Kualitatif Kandungan Bunga Kenanga (Cananga odorata) Secara Fitokimia dengan Menggunakan Pelarut Etanol’, Journal of Research and Education Chemistry, 2(1), p. 43. doi: 10.25299/jrec.2020.vol2(1).4783.
Report, C. (2023) ‘Case Report Psychodynamic Overview of Generalized Anxiety’, 7(1). doi: 10.33086/mhsj.v7i1.3558.
Rohn, T. T. et al. (2023) ‘ Genetic Modulation of the HTR2A Gene Reduces Anxiety-Related Behavior in Mice’, PNAS Nexus, 2(6), p. 1-13. doi: 10.1093/pnasnexus/pgad170.
Safran, M. et al. (2021) ‘Bab 2 Rangkaian GeneCards’, p. 27-56.
Shofi, M. (2022) ‘Studi In Silico Senyawa Kuarsetin Daun Kencana Ungu (Ruellia tuberosa L.) Sebagai Agen Antikanker Payudara’, Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya, 2(1), p. 1-9. doi: 10.56399/jst.v2i1.13.
Suhendi, H. and Supriadi, A. (2020) ‘Sistem Pakar Diagnosa Gangguan Kecemasan Menggunakan Metode Certainty Factor Berbasis Website’, Naratif : Jurnal Nasional Riset, Aplikasi dan Teknik Informatika, 2(2), p. 13-23. doi.org/10.53580/naratif.v2i2.94.
Sundara, A. K. et al. (2022) ‘Review Article : Aromaterapi Sebagai Terapi Stres Dan Gangguan Kecemasan’, Jurnal Buana Farma, 2(2), p. 78-84. doi: 10.36805/jbf.v2i2.396.
Syed, S. A. and Nemeroff, C.B. (2017) ‘Early Life Stress, Mood, and Anxiety Disorders’, Chronic Stress, 1. doi: 10.1177/2470547017694461.
Szklarczyk, D. et al. (2021) ‘Database STRING pada Tahun 2021 : dapat Disesuaikan Jaringan Protein-Protein, dan Fungsional Karakterisasi Gen/ Pengukuran yang Diunggah Pengguna Set’, 49, p. 605-612.
Tan, L. T. H. et al. (2015) ‘Traditional Uses, Phytochemistry, and Bioactivities of Cananga odorata (ylang-ylang)’, Evidence-based Complementary and Alternative Medicine, 2015. doi: 10.1155/2015/896314.
Ulfianasari, E., Winahyu, K. M. and Nainar, A. A. A. (2022) ‘Cyberbullying dan kecemasan remaja : Sebuah studi deskriptif’, Jurnal Ilmiah Keperawatan Indonesia, 6(1), p. 80–89).
Vildayanti, H., Puspitasari, I.M. and Sinuraya, R.K. (2018) ‘Review: Farmakoterapi Gangguan Anxietas’, Farmaka, 16(1), p. 196-213.
Wulandari, A. S., Ferawati, D. and Nurhayani, O. (2019) ‘Morfologi dan Mutu Fisik Benih Kenanga (Cananga odorata (Lam.) Hook.f. & Thomson forma genuina) Morphology and Physical Quality of Cananga Seeds (Cananga odorata (Lam.) Hook.f. & Thomson forma genuina)’, Jurnal Silvikultur Tropika, 10(2), p. 95–99.
Yassir, M. and Asnah, A. (2019) ‘Pemanfaatan Jenis Tumbuhan Obat Tradisional Di Desa Batu Hamparan Kabupaten Aceh Tenggara’, BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan, 6(1), p. 17. doi: 10.22373/biotik.v6i1.4039.
Zhou, Y. et al. (2017) ‘The Effects of NR3C1 Polymorphisms and Paternal/ Maternal Parenting Styles on Chinese Adolescent Anxiety Disorders’, Acta Psychologica Sinica, 49(10), p. 1287. doi: 10.3724/sp.j.1041.2017.01287
Published
2023-11-13
How to Cite
MARETHA, Tri Luthfiana et al.
Network Pharmacology Analysis of Cananga odorata as a Treatment for Anxiety Disorders.
Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR), [S.l.], v. 3, p. 137-153, nov. 2023.
ISSN 2827-7848.
Available at: <http://conferences.uin-malang.ac.id/index.php/planar/article/view/2479>. Date accessed: 04 may 2024.
doi: https://doi.org/10.18860/planar.v3i0.2479.
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