The Therapeutic Role of Olea europaea in Alcohol Dependence Base in Network Pharmacology Analysis
Abstract
Alcohol dependence is a state of alcohol becoming a vital part of the life of a person who consumes it; when discontinued, it can lead to a wide range of physical and mental health disorders as well as a decrease in life productivity in people with alcohol dependence. Olea Europaea (OE) is a plant capable of treating alcohol dependence. The method used in silico-based pharmacological grid analysis to determine the ability of the OE compound to treat alcohol dependence. EO compound data is obtained from the KnapSack database, absorption, distribution, metabolism, and excretion (ADME) screening using SwissADME, target protein prediction using SwissTargetPrediction, Gene cards, venny, pharmacological grid analysis with String-DB, visualization with Cytoscape 3.10.0. Results are obtained from 63 OE compounds, and 17 have ADME criteria matching the drug compounder (Drug Likeness/DL). The pathways that correlate with therapy are dopamine receptors, dopamine transporter, serotonin receptor, gamma-aminobutyric acid receptor, and toll-like receptors for known therapeutic target proteins: OPRM1, DRD2, ALDH2, ADH1B, ADH1A, ADH1C, ADH4, ADH7, SLC6A3, CNR1, POMC, ARRB2, and NCS1. Compounds associated with alcohol dependency therapy include Hexanal, Nonadienal, Octanal, 3-Hexenal, 3-Methyl-butanal, Methyl nominate, Cinchonidine, cinchonine, (9S)-10,11-Dihydrocinchonan-9-ol, Oleuropeic acid, Butyl acetate, cis-3-hexenyl acetate, and (S)-2,3-Epoxysqualene. Based on the findings, OE is a potential drug candidate for alcohol dependence.
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Lin, G. et al. (2016) ‘VennPainter : A Tool for the Comparison and Identification of Candidate Genes Based on Venn Diagrams’, pp. 5–8. Available at: https://doi.org/10.1371/journal.pone.0154315.
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Rudik, A. et al. (2018) ‘MetaTox - Web Application for Generation of Metabolic Pathways and Toxicity Estimation’. Available at: https://doi.org/10.1142/S0219720019400018.
Sebold, M. et al. (2021) ‘Association of the OPRM1 A118G polymorphism and Pavlovian-to- instrumental transfer : Clinical relevance for alcohol dependence’. Available at: https://doi.org/10.1177/0269881121991992.
Stelzer, G. et al. (2016) ‘The GeneCards Suite : From Gene Data Mining to Disease GenomeSequence Analyses’, (June), pp. 1–33. Available at: https://doi.org/10.1002/cpbi.5.
Szklarczyk, D. et al. (2019) ‘STRING v11 : protein – protein association networks with increased coverage , supporting functional discovery in genome-wide experimental datasets’, 47(November 2018), pp. 607–613. Available at: https://doi.org/10.1093/nar/gky1131.
Szklarczyk, D. et al. (2021) ‘The STRING database in 2021 : customizable protein – protein networks , and functional characterization of user-uploaded gene / measurement sets’, 49(November 2020), pp. 605–612. Available at: https://doi.org/10.1093/nar/gkaa1074.
Tritama, T.K. (2015) ‘Konsumsi Alkohol dan Pengaruhnya terhadap Kesehatan’, Journal Majority, 4(8), pp. 7–10. Vol 4, No 8 (2015) Tritama.
Wall, T.L., Luczak, S.E. and Hiller-Sturmhöfel, S. (2016) ‘Biology, genetics, and environment: Underlying factors influencing alcohol metabolism’, Alcohol Research: Current Reviews, 38(1), pp. 59–68.
Weiland, B.J., Yorkwilliams, S. and Hutchison, K.E. (2020) ‘DRD2 Promoter Methylation and Measures of Alcohol Reward: Functional Activation of Reward Circuits and Clinical Severity’, 24(3), pp. 539–548. Available at: https://doi.org/10.1111/adb.12614.DRD2.
Xu, M. et al. (2017) ‘Genetic influences of dopamine transport gene on alcohol dependence: A pooled analysis of 13 studies with 2483 cases and 1753 controls’. Available at: https://doi.org/10.1016/j.pnpbp.2010.11.001.Genetic
Published
2023-11-13
How to Cite
AWWALUDDIN, Faiznanda et al.
The Therapeutic Role of Olea europaea in Alcohol Dependence Base in Network Pharmacology Analysis.
Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR), [S.l.], v. 3, p. 201-215, nov. 2023.
ISSN 2827-7848.
Available at: <http://conferences.uin-malang.ac.id/index.php/planar/article/view/2486>. Date accessed: 04 may 2024.
doi: https://doi.org/10.18860/planar.v3i0.2486.
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