Systematic Literature Review of Bioactive Compounds in Persimmon Vinegar Against Breast Cancer
Abstract
Kanker payudara adalah tumor ganas atau benjolan abnormal yang berkembang di jaringan payudara, baik dari epitel duktus maupun lobulus. Pada tahun 2022, jumlah kasus baru kanker payudara di seluruh dunia mencapai 2,3 juta. Terapi kanker payudara meliputi berbagai metode pengobatan seperti radiasi dan kemoterapi. Namun, terapi ini tidak selektif dan merusak sel normal, menyebabkan efek samping yang merugikan bagi pasien. Cuka kesemek memiliki berbagai manfaat kesehatan, tetapi potensinya dalam pengobatan kanker payudara masih terbatas. Studi ini bertujuan untuk mengidentifikasi senyawa potensial dalam cuka kesemek dan mekanisme kerjanya melawan kanker payudara. Studi ini dilakukan dengan menggunakan metode Tinjauan Literatur Sistematis (SLR) menggunakan basis data Google Scholar, Pubmed, dan ScienceDirect. Hasil menunjukkan bahwa terdapat 13 artikel yang memenuhi kriteria inklusi. Berdasarkan analisis, terdapat 24 senyawa yang memiliki aktivitas antikanker payudara, yaitu β-kriptoksantin, zeaxanthin, β-karoten, likopen, asam galat, katekin, epigallocatechin, asam p-kumarat, asam vanilat, asam kafeat, epikatekin, asam ferulat, gallocatechin, asam klorogenat, epikatekin galat, prosianidin A2, rutin, katekin hidrat, floridzin, asam tartarat, asam suksinat, asam sitrat, betaine, dan 2,3-butanediol. Hasil ini menunjukkan bahwa cuka kesemek berpotensi sebagai pengobatan kemopreventif untuk kanker payudara, memberikan dasar untuk penelitian lebih lanjut tentang pengembangannya.
References
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Cecati, M., Pozzi, V., Pompei, V., Schiavoni, V., Fumarola, S., Romagnoli, A., Tossetta, G., Montana, A., Polizzi, A., Sartini, D., & Campagna, R. (2026). Cisplatin as a Xenobiotic Agent: Molecular Mechanisms of Actions and Clinical Applications in Oncology. Journal of Xenobiotics, 16(1), 9. https://doi.org/10.3390/jox16010009
Chen, H., Chen, T., Giudici, P., & Chen, F. (2016). Vinegar functions on health: Constituents, sources, and formation mechanisms. Comprehensive Reviews in Food Science and Food Safety, 15(6), 1124-1138. doi: 10.1111/1541-4337.12228 https://doi.org/10.1111/1541-4337.12228
Choudhary, R., Singh, A., Upadhyay, A., Singh, R., Thangalakshmi, S., Dar, A. H., ... and Shukla, S. 2023. Exotic god fruit, persimmon (Diospyros kaki): Pharmacological importance and human health aspects. eFood, 4(1), e52. https://doi.org/10.1002/efd2.52
Cristiandari, E. M., 2018, Uji efek ekstrak dan fraksinasi daun salung (Psychotria viridiflora Reinw. Ex. Blume) pada sel kanker payudara t47d. JPP (Jurnal Kesehatan Poltekkes Palembang)., 13: 9-20.
Dhyani, P., Sati, P., Chand Attri, D., Sharma, E., Soni, R., Sharifi‐Rad, J. and Calina, D., 2025. Phloridzin as a Nutraceutical for Cancer Prevention and Therapy: A Comprehensive Review of Its Mechanisms, Bioavailability Challenges and Future Applications. Food science & nutrition, 13(8), p.e70744. https://doi.org/10.1002/fsn3.70744
Direito, R., Rocha, J., Sepodes, B., and Eduardo-Figueira, M. 2021. From Diospyros kaki L.(persimmon) phytochemical profile and health impact to new product perspectives and waste valorization. Nutrients, 13(9), pp. 3283. https://doi.org/10.3390/nu13093283
Fahmy, S.A., Ramzy, A., El Samaloty, N.M., Sedky, N.K. and Azzazy, H.M.E.S., 2023. PEGylated chitosan nanoparticles loaded with betaine and nedaplatin hamper breast cancer: in vitro and in vivo studies. ACS omega, 8(44), pp.41485-41494. doi: 10.1021/acsomega.3c05359
Fong, Y., Tang, C.C., Hu, H.T., Fang, H.Y., Chen, B.H., Wu, C.Y., Yuan, S.S., Wang, H.M.D., Chen, Y.C., Teng, Y.N. and Chiu, C.C., 2016. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chinese medicine, 11(1), p.45. DOI 10.1186/s13020-016-0116-7
Gan, T. J. 2017. Poorly controlled postoperative pain: prevalence, consequences, and prevention. Journal of pain research, pp. 2287-2298. https://doi.org/10.2147/JPR.S144066
Ge, Y., Wu, Y., Aihaiti, A., Wang, L., Wang, Y., Xing, J., Zhu, M. and Hong, J., 2025. The metabolic pathways of yeast and acetic acid bacteria during fruit vinegar fermentation and their influence on flavor development. Microorganisms, 13(3), p.477. https://doi.org/10.3390/microorganisms13030477
Gloria, N. F., Soares, N., Brand, C., Oliveira, F. L., Borojevic, R., & Teodoro, A. J. (2014). Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer research, 34(3), 1377-1386.
Hao, X., Gao, Z. and Hu, M., 2025. Anti-tumor role and molecular mechanism of vanillic acid. Discover Oncology, 16(1), p.20.
Hassan, M.S., Khalid, T., Akhlaq, M., Hameed, A., Sharif, F., Rana, S. and Uroos, M., 2025. Therapeutic potential of betaine and its derivatives in cancer treatment: a comprehensive review. RSC advances, 15(26), pp.20605-20622. doi: 10.1039/D5RA00755K
Hosseini, E., Tsegay, Z.T., Smaoui, S. and Varzakas, T., 2025. Lactic Acid Bacteria in Vinegar Fermentation: Diversity, Functionality and Health Benefits. Foods, 14(4), p.698. https://doi.org/10.3390/foods14040698
Hosseininejad, S., González, C.M., Hernando, I. and Moraga, G., 2022. Valorization of persimmon fruit through the development of new food products. Frontiers in Food Science and Technology, 2, p.914952. doi: 10.3389/frfst.2022.914952
Khazbak, A. E. R. A., Salem, S. M., Rady, H. H., and Bashandy, M. A. (2023). Regulation of breast cancer stem cells associated-miRNAs by ginger and persimmon extracts. Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology, 15(1), pp. 109-119. 10.21608/EAJBSC.2023.282963
Kuang, H., Ye, Q., Tong, J., Fu, H., Shi, Z., Zhu, B. and Yang, G., 2026. Lactobacillus plantarum-fermented persimmon juice alleviates alcohol-induced hepatic ferroptosis by activating the Keap1/Nrf2 antioxidant axis. Frontiers in Microbiology, 17, p.1679233. doi: 10.3389/fmicb.2026.1679233
Lee, HL, Lin, CS, Kao, SH dan Chou, MC, 2017. Asam galat menginduksi penghentian fase G1 dan apoptosis sel kanker payudara triple-negatif MDA-MB-231 melalui sumbu p38 mitogen-activated protein kinase/p21/p27. Obat antikanker , 28 (10), hlm. 1150-1156. Doi: 10.1097/CAD.0000000000000565
Lee, S. (2025). Influence of pH on the cytotoxic activity of organic acids against breast cancer cells. Bioorganic & Medicinal Chemistry, 118330.
Liambo, I. S.; Frisitiohady, A.; Malaka, M. H. dan Kendari, M., 2022, Review: Patofisiologi, epidemiologi, dan lini sel kanker payudara. Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan., 8:17-22
Mutiah, R., Indradmojo, C., Dwi, H. H., Griana, T. P., Listyana, A., & Ramdhani, R. (2017). Induction of apoptosis and phase-cell cycle inhibition of G0-G1, S, G2-M of T47D breast cancer cells on treatment with ethyl acetate fraction of jackfruit parasite leaves (Macrosolen cochinensis). Journal of Applied Pharmaceutical Science, 7(10), 138-143. DOI: 10.7324/JAPS.2017.71020
Mutiah, R., Rachmawati, E., Taufik, I., Sari, R.A., Rahmadani, N. and Milliana, A., 2025. Potential of Persimmon (Diospyros kaki L.) Compounds for the Treatment of Breast Cancer: A Network Pharmacology Study. Tropical Journal of Natural Product Research, 9(8). DOI 10.26538/tjnpr/v9i8.30
Özdemir, N., Budak, N.H., Filiz, B.E. and Özer, E., 2022. Occurrences and changes in aroma‐associated volatile compound profiles and prominent bioactive compounds at different stages of persimmon vinegar production process. Journal of Food Processing and Preservation, 46(11), p.e17048. https://doi.org/10.1111/jfpp.17048
Ren, J. G., Seth, P., Ye, H., Guo, K., Hanai, J. I., Husain, Z. and Sukhatme, V. P., 2017. Citrate suppresses tumor growth in multiple models through inhibition of glycolysis, the tricarboxylic acid cycle and the IGF-1R pathway. Scientific reports, 7(1), 4537. doi: 10.1038/s41598-017-04626-4.
Rezaei-Seresht, H., Cheshomi, H., Falanji, F., Movahedi-Motlagh, F., Hashemian, M. dan Mireskandari, E., 2019. Aktivitas sitotoksik asam kafeik dan asam galat terhadap sel kanker payudara manusia MCF-7: Studi in silico dan in vitro. Jurnal fitomedisin Avicenna , 9 (6), p.574. doi: 10.22038/ajp.2019.13475
Rizka, A.; Akbar, M. K. and Putri, N. A., 2022, Carcinoma Mammae Sinistra T4bN2M1 Metastasis Pleura. AVERROUS: Jurnal Kedokteran Dan Kesehatan Malikussaleh., 8:23-31.
Sahab, N. R. M. 2023. Jus Buah Terfermentasi sebagai Minuman Probiotik. Jurnal Riset Teknologi Pangan Dan Hasil Pertanian (RETIPA), pp. 18-28. https://doi.org/10.54367/retipa.vi.3019
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Published
2026-08-08
How to Cite
MUTIAH, Roihatul et al.
Systematic Literature Review of Bioactive Compounds in Persimmon Vinegar Against Breast Cancer.
Proceedings of International Pharmacy Ulul Albab Conference and Seminar (PLANAR), [S.l.], v. 5, p. 54-65, aug. 2026.
ISSN 2827-7848.
Available at: <https://conferences.uin-malang.ac.id/index.php/planar/article/view/3865>. Date accessed: 31 aug. 2026.
doi: https://doi.org/10.18860/planar.v5i0.3865.
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