Senna occidentalis and Cyanthillium patulum: Indonesian Herbs as Source for Antimalarial Agents

Main Article Content

Antonius Nugraha Widhi Pratama Dwi Koko Pratoko Bawon Triatmoko Naura Bathari Winarto Tinton Agung Laksono Ari Satia Nugraha

Abstract

As stated in history, antimalarial agents are closely related to natural product research. Senna occidentalis and Cyanthillium patulum are among many potential medicinal plants based on ethno-traditional knowledge. This study was conducted to profile the activity for antimalarial from the crude methanol extract of the plant, which were collected from Malang,-East Java and Klaten-Central Java, Indonesia. Antimalarial assay against Plasmodium falciparum was done in vitro. Chemical identification using Dragendorff's reagent and spectral analysis from 1H-NMR spectroscopy was conducted. The results demonstrate that the extract of leaves of S. occidentalis constitutes typical phenolic backbones whereas C. patulum constitutes sugar derivatives and
terpenoids. Crude methanol extracts of the two species possessed significant antimalarial activity. The further experiment is required to define the responsible antimalarial compounds.

Article Details

How to Cite
PRATAMA, Antonius Nugraha Widhi et al. Senna occidentalis and Cyanthillium patulum: Indonesian Herbs as Source for Antimalarial Agents. Proceedings of the International Conference on Green Technology, [S.l.], v. 10, p. 9-12, dec. 2019. ISSN 2580-7099. Available at: <http://conferences.uin-malang.ac.id/index.php/ICGT/article/view/1111>. Date accessed: 07 apr. 2020.
Section
Pharmacy

References

1] D. J. Conway, “Molecular epidemiology of malaria,” Clin. Microbiol. Rev., vol. 20, no. 1, pp. 188–204, Jan. 2007.
[2] J. Cox-Singh and B. Singh, “Europe PMC Funders Group Knowlesi malaria : newly emergent and of public health importance ?,” Trends Parasitol., vol. 24, no. 9, pp. 406–410, 2008.
[3] N. J. White, “Plasmodium knowlesi : the fifth human malaria
parasite,” Clin. Infect. Dis., vol. 46, pp. 172–173, 2008.
[4] B. E. Barber, G. S. Rajahram, M. J. Grigg, T. William, and N. M. Anstey, “World Malaria Report : time to acknowledge Plasmodium knowlesi malaria,” Malar. J., vol. 16, no. 135, 2017.
[5] World Health Organization, "Q-A on the Phase 3 trial results for malaria vaccine RTS, S/AS01," WHO, 2018.
[6] T. A. Ghebreyesus and K. Admasu, “Countries must steer new response to turn the malaria tide,” Lancet (London, England), vol. 392, no. 10161, pp. 2246–2247, Nov. 2018.
[7] World Health Organization, “WHO Global technical strategy for malaria for 2016–2030,” World Health Organization, Geneva, 2016.
[8] Medecins Sans Frontieres, "World Malaria Day: five challenges in the fight against the disease," 2016.
[9] D. Butler, “Malaria vaccine results face scrutiny,” Nature, vol. 478, no. 7370, pp. 439–440, Oct. 2011.
[10] D. Butler, “Malaria vaccine gives disappointing results,” Nature, Nov. 2012.
[11] C. H. Coelho, J. Y. A. Doritchamou, I. Zaidi, and P. E. Duffy,
“Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium.,” NPJ vaccines, vol. 2, p. 34, 2017.
[12] I. Kleinschmidt et al., “Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO￾coordinated, prospective, international, observational cohort study,”
Lancet Infect. Dis., vol. 18, no. 6, pp. 640–649, Jun. 2018.
[13] J. Pryce, M. Richardson, and C. Lengeler, “Insecticide-treated nets for preventing malaria,” Cochrane Database Syst. Rev., no. 11, Nov. 2018.
[14] D. Menard and A. Dondorp, “Antimalarial DrugResistance: A Threat to Malaria Elimination.,” Cold Spring Harb. Perspect. Med., vol. 7, no. 7, p. a025619, Jul. 2017.
[15] C. Chen, “Development of antimalarial drugs and their application in China: a historical review,” Infect. Dis. Poverty, vol. 3, no. 1, p. 9, Mar. 2014.
[16] E. G. Tse, M. Korsik, and M. H. Todd, “The past, present and future of anti-malarial medicines,” Malar. J., vol. 18, no. 1, p. 93, Dec. 2019.
[17] I. Elyazar et al., “Plasmodium falciparum Malaria Endemicity in Indonesia in 2010,” PLoS One, vol. 6, p. e21315, Jun. 2011.
[18] J. R. Hutapea and Djumidi, Inventaris tanaman obat Indonesia I jilid 2. Departemen Kesehatan dan Kesejahteraan Sosial RI, 2001.
[19] Eisai Indonesia, Herb Index Indonesia, Eisai Indonesia. Jakarta, 1986.
[20] Katno, Inventaris tanaman obat Indonesia VI. Jakarta: Departemen Kesehatan RI, 2006.
[21] J. P. Yadav, V. Arya, S. Yadav, M. Panghal, S. Kumar, and S.
Dhankhar, “Cassia occidentalis L.: A review on its ethnobotany,
phytochemical and pharmacological profile.,” Fitoterapia, vol. 81, no. 4, pp. 223–230, 2010.
[22] K. Murugan et al., “Mosquitocidal and antiplasmodial activity of Senna occidentalis (Cassiae) and Ocimum basilicum (Lamiaceae) from Maruthamalai hills against Anopheles stephensi and Plasmodium falciparum,” Parasitol. Res., vol. 114, no. 10, pp. 3657–3664, 2015.
[23] J. S. Kayembe, K. M. Taba, K. Ntumba, M. T. C. Tshiongo, and T. K. Kazadi, "In vitro antimalarial activity of 20 quinones isolated from four plants used by traditional healers in the Democratic Republic of Congo.," J. Med. Plants Res., vol. 4, no. 11, pp. 991–994, 2010.